Need advice on Stem Cell treatment for CP

Ashley - posted on 05/08/2012 ( 5 moms have responded )

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Marlee was born via emergency C-section at 32 week, due to delayed delivery (physician error) she went 4 minutes without oxygen and was trapped breach in my birth canal. Subsequently, she has been diagnosed with hemi CP, complex partial seizures, idioventricular arrhythmia (with v-tach), and strabismus Exotropia. We have been doing OT and PT since she was 10 days old. We also did aquatic therapy for 8 months. She has also been in speech therapy for 6 months. We have done Botox once, but she went into V-tach and almost died. We are debating doing Botox again but this time with a cardiologist present. Since her problems were caused by physician error, I feel a deep need to 'fix' her. I have been researching Stem Cell therapy at Duke and Georgia. I am wanting some advice from anyone who has tried it or is thinking about trying it. (We did not have the opportunity to save her cord blood because of everything that happened. So we would need to use cord blood from a bank) Any advice or information would be helpful and greatly appreciated!

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Katherine - posted on 05/08/2012

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According to Duke University, which is utilizing autologous (patient’s own) cord blood-derived stem cells to treat children with cerebral palsy in an ongoing clinical trial, “Cerebral palsy results from in utero or perinatal injury to the developing brain, often through stroke, hypoxic insult or hemorrhage. Currently available treatments for patients with cerebral palsy are supportive, but not curative. Umbilical cord blood (UCB) has been shown to lessen the clinical and radiographic impact of hypoxic brain injury and stroke in animal models. UCB also engrafts and differentiates in brain, facilitating neural cell repair, in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation. We hypothesize that, in the setting of brain injury, infusion of autologous UCB will facilitate neural cell repair resulting in improved function in pediatric patients with cerebral palsy.”

Since the beginning of this clinical trial at Duke, parents have been reporting functional improvement in their children after receiving cord blood-derived stem cells.

Because we utilize allogeneic cord blood-derived stem cells, we are able to offer treatment to any qualified patient, not just those who saved their own cord blood at birth. We will discuss several additional advantages of allogeneic cord-derived stem cells below.
Which kinds of stem cells are utilized for CP treatment and how are they collected?

The Stem Cell Institute leverages adult stem cells from expanded and fresh human umbilical cord matrix and cord blood (allogeneic mesenchymal and CD34+) to treat cerebral palsy. Both types of stem cells are harvested from donated umbilical cords and cord blood. In accordance with International Blood Bank standards, all umbilical cord-derived stem cells are rigorously screened for viruses and bacteria at Medistem Labs before they are approved for use in patients.
What are the advantages of treating with allogeneic cord blood and matrix-derived stem cells?

Advantages of allogeneic umbilical cord-derived stem cells over autologous cord blood cells include:

• Anyone can be treated because there is no requirement to use the patient’s own banked cord blood
• Allogeneic stem cells can be administered multiple times over the course of days in uniform dosages that contain high cell counts, not just once.
• Umbilical cord matrix provides an abundant supply of mesenchymal stem cells. On the other hand, the cord blood itself contains very few mesenchymal cells.

Advantages of allogeneic umbilical cord-derived stem cells over autologous bone marrow stem cells include:

• No need to collect stem cells from the patient’s hip bone under general anesthesia, which for small children and their parents, can be an unpleasant ordeal.
• Because they are collected right after (normal) birth, umbilical cord-derived cells are much more potent than their “older” counterparts like bone marrow-derived cells for instance.
• Umbilical cord matrix provides an abundant supply of mesenchymal stem cells. On the other hand, bone marrow contains very few mesenchymal cells.

Caution Icon Umbilical cord-derived stem cells pose no rejection risk because the body does not recognize them as foreign.
How are the stem cells administered during CP treatment?

A licensed physician administers the stem cells intravenously (IV). Depending upon the age and physical size of the patient, the stem cells might also be administered intrathecally (into the spinal fluid) by an experienced anesthesiologist. Intrathecal injection allows the stem cells to bypass the mature blood-brain barrier efficiently and migrate throughout the central nervous system.

The cerebral palsy treatment protocol typically takes 5 days.

STEM CELL TREATMENT – CEREBRAL PALSY: PROTOCOL OUTLINE

Option 1:

• Treatment length (Monday – Friday): 5 days
• 4 intravenous infusions of expanded/non-expanded donor mesenchymal and CD34+ stem cells

Option 2:

• Treatment length (Monday – Friday): 5 days
• 2 intravenous infusions of expanded/non-expanded donor mesenchymal and CD34+ stem cells
• 2 intrathecal infusions of expanded/non-expanded donor mesenchymal and CD34+ stem cells

What about follow-up after we return home from Panama?

Our primary concern is to ensure each patient’s safety and proper follow-up plays an essential role in that process. Regular follow-up also enables us to evaluate efficacy and improve treatment protocols based on observed outcomes.

Therefore, our medical staff will be contacting you after 1 month, 3 months, 4 months, and 1 year to monitor your child’s progress.
May I contact parents of successfully treated patients?

Yes! Once our medical team has evaluated your child and approved him or her for treatment, your patient coordinator will help you get in touch with them.

We also welcome you to view testimonials, news articles and videos from treated cerebral palsy patients on our cerebral palsy patient experiences page.
How do I request more information?

You may contact us by telephone 1 (800) 980-STEM (toll-free in US) and 1 (954) 636-3390 or by web-based inquiry form.
To find out if you are eligible, Apply for Treatment Today:

To apply for stem cell treatment, please complete this Patient Application Form.
http://www.cellmedicine.com/treatment/ce...



Sounds promising!

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Xushiyue - posted on 11/21/2013

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In China we see some children with CP use stem cell treatment.
Some parents told it is better,some not effective.

Your child is very young.If you persist to do some PT and OT.it is better.

Stephen Daniel - posted on 08/08/2012

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Please, I am not advertising as my mum does not sell anything and has no ads on her site..for info and personal answers from a adult stem cell transplant patient please visit her bog and ask her and or read all about it. http://stemcellpatient.blogspot.co.nz/

Ashley - posted on 05/09/2012

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I appreciate your help, but I read this already. Thank you for finding the info anyway.

Katherine - posted on 05/08/2012

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I actually donated my daughters cord blood. I can use it if I need to, that's the great thing about donating. It's free too. It's a shame they couldn't save it :(

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