User - posted on 08/24/2011 ( 4 moms have responded )




I'm looking for other moms with kids with MCADD I have fb and you can look me up there I have so many questions my daughter is 4 and is doing real well anyone else's child have a fishy smell due to medicine what medicine does ur child take how do u deal with it day to day with food wise are ur kids bigger? I'm just looking for parents to talk to about it

Brenda Fambrough


Jane - posted on 08/29/2011




@Pamela MCADD = Medium Chain Acyl-CoA Dehydrogenase Deficiency (although I must admit that I thought it might be eating McDonald's food constantly).

"During times of fasting, the body uses fat as a major source of energy. Fats are catabolized through a process called beta-oxidation. The overall reaction involves several different enzymes which break down long-chain fats to medium-chain fats, medium-chain fats to short-chain fats, and short-chain fats to ketone bodies and acetyl-CoA. The former are used directly for energy and the latter enter the Kreb cycle to generate ATP and reducing equivalents. Medium-chain fatty acids are broken down through a cycle using the enzyme medium chain acyl-CoA dehydrogenase. Decreased or absent activity of this enzyme results in MCADD...There is no "typical" presentation, although prolonged fasting of any type can precipitate an event. Intercurrent illness, which results in increased energy needs, is usually present. With prolonged fasting, greater than 12 to 14 hours, lipolysis and hepatic fatty acid oxidation become activated. Plasma levels of free fatty acids rise but ketones remain inappropriately low. Patients then become hypoglycemic with severe symptoms of lethargy, nausea, and vomiting. Hepatomegaly is sometimes noted. Even if children with MCADD present with glucose levels within the normal range, they can decompensate quickly, as glucose is catabolized instead of fats. Without rapid intervention with IV glucose, patients can rapidly progress to coma within 1 to 2 hours. Seizures may occur and, without appropriate treatment, sudden death from acute cardiorespiratory arrest may follow. Permanent brain damage after successful resuscitation has been described. Up to 25% of undiagnosed infantile MCADD sufferers do not survive the first attack."

Google is your friend. :-)


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Pamela - posted on 08/29/2011




It would help if you list what MCADD is. Sorry, not all of us know the "umpteen" acronymns for so-called diseases or maladies.

I know ADHD and similar ones because I teach and those acronyms are familiar in schools. Please inform me what MCADD stands for and perhaps I can offer advice.

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